셀루션 [Cellution]

ZL41 Cell Features Specifically for Life Sciences
NEW SRRF-Stream+	The most cost-effective and easy way to add super-resolution down to 100 nm to your existing microscope (ZL41 Cell only).
LightScan PLUS	Optimise signal strength and confocality in applications such as Scanned Light Sheet Microscopy and Line Scanning Confocal Microscopy with LightScan+.
FCS mode	Obtain the fastest possible speeds from minimal height ROIs configured for Fluorescence Correlation Spectroscopy experiments. ZL41 Cell 4.2 outputs a sustained 26,041 fps (2048 (w) x 8 (h) ROI) with exceptional temporal resolution.
GPU Express	Simplify and optimize data transfer from the camera – ideal for today’s data intensive imaging experiments. Leverage CUDA-enabled NVidia GPU processing to accelerate the data acquisition pipeline with GPU Express.

Feature	Benefit
NEW Enhanced image quality	Updated QC processes ensure every ZL41 Cell delivers optimal image quality. Ultra-low PRNU for clear noise free images whatever the image conditions.
NEW Sensor chamber	An updated sensor chamber provides even greater long-term protection from condensation in high humidity environments (3 year chamber warranty).
NEW Python ready	Python wrapper integration and full supporting documentation in latest camera SDK helps integration and full control of custom-build systems.
QEmax boosted to 82%	High efficiency across visible/NIR, optimized for all common fluorophores. Shorter exposures, reduced phototoxicity, lower dye concentrations.
~ 1 e read noise	Noise floor down to 0.9 e-. Lower detection limit than any CCD.
Market leading USB 3.0 speed	ZL41 Cell delivers up to 53 fps full resolution. Follow dynamic processes with improved temporal resolution.
100 fps (Camera Link)	ZL41 Cell offers Camera Link for maximum sustained frame rates.
Global shutter option	Global shutter (ZL41 Cell 5.5) for 'interline CCD mode' freeze frame capture of fast moving/changing events.
Extended dynamic range	Unique 'dual gain amplifier' sensor architecture offering dynamic range of 33,000:1.
12-bit and 16-bit modes	12-bit mode for smaller file size and absolute fastest frame rates through USB 3.0; 16-bit mode for full dynamic range.
Better than 99.8% linearity	Unparalleled quantitative measurement accuracy across the full dynamic range.

Quality, Throughput, Performance, Accessibility…

High sensitivity & wide dynamic range – quantify very weak and very bright structures with one image.
Superb image quality – high resolution and uniform backgrounds for publication quality imaging.
Capture everything – large field of view matches that of modern microscopes. Achieve better statistics and higher throughout in high content experiments.
Blazingly fast – more and more studies of cell processes require greater temporal resolution. ZL41 Cell is fast and importantly keeps noise low.
Ease of use – start imaging immediately with helpful documentation and features like Python integration in camera SDK.

A camera for any application or technique

	sCMOS				EMCCD		CCD
Application Requirement	ZL41 Cell 5.5	ZL41 Cell 4.2	Sona-6	Sona-11	iXon 897 Life/Ultra	iXon 888 Life/Ultra	iKon-M
Capture weakest signals	■ ■ ■ □ □	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ □ □ □ □
High sensor resolution	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ □ □	■ □ □ □ □	■ ■ □ □ □	■ □ □ □ □
Image a wide field of view	■ ■ ■ ■ ■	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ ■	■ ■ □ □ □	■ ■ □ □ □	■ □ □ □ □
High speed imaging	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ ■	■ ■ ■ □ □	■ ■ □ □ □	■ ■ □ □ □	■ □ □ □ □
High dynamic range	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ □	■ ■ ■ ■ ■	■ ■ □ □ □	■ ■ □ □ □	■ ■ □ □ □
Long exposure suitability	■ □ □ □ □	■ □ □ □ □	■ □ □ □ □	■ □ □ □ □	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■
Quantitative measurements	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■	■ ■ ■ ■ ■

■ □ □ □ □ - Not suitable ■ ■ ■ ■ ■ - Optimal

SRRF-STREAM+

Want to enable fast and easy super-resolution down to 100 nm? Our exclusive camera-based technology enables super-resolution microscopy on conventional modern fluorescence microscopes in real-time.

SRRF (Super-Resolution Radial Fluctuations), is a highly effective approach to super-resolution developed by the Henriques research group (Gustafsson et al., 2016). Andor’s unique and exclusive implementation of SRRF-Stream+ allows camera-based real-time super- resolution with low illumination intensities and normal fluorescent labels.

Capture vibrant images – with stunning detail and high contrast.
Conventional fluorophores – simple labelling, no photo- switching required.
Cost-effective – convert conventional fluorescence microscopes to super-resolution microscopes.
Real time – enhanced workflow, avoids post-processing. View in ‘Live Mode’.
Low excitation intensities – prolonged live cell observations & accurate physiology.

STORM, PALM & DNA PAINT

The high sensitivity, low noise and high-speed capabilities of ZL41 Cell are well suited to single molecule based ‘STORM / PALM’ and DNA PAINT approaches, revealing biological information down to ~10 nm.

Technical Specifications

Model	ZL41 Cell 5.5			ZL41 Cell 4.2
Active pixels (W x H)	2560 x 2160 (5.5 Megapixel)			2048 x 2048 (4.2 Megapixel)
Sensor size	16.6 x 14.0 mm 21.8 mm diagonal			13.3 x 13.3 mm 18.8 mm diagonal
Pixel readout rate (MHz)	200 (100 MHz x 2 sensor halves) 560 (280 MHz x 2 sensor halves)			216 (108 MHz x 2 sensor halves) 540 (270 MHz x 2 sensor halves)
Read noise (e ) Median [rms]	@ 200 MHz @ 560 MHz	Rolling Shutter 0.9 [1.2] 1.2 [1.6]	Global Shutter 2.3 [2.5] 2.4 [2.6	@ 216 MHz @ 540 MHz	Rolling Shutter 0.90 [1.1] 1.10 [1.3]
Maximum Quantum Efficiency	64%			82%
Sensor Operating Temperature Air cooled Water cooled	0ºC (up to 30ºC ambient) -10ºC*			0ºC (up to 27ºC ambient) -10ºC*
Dark current, e /pixel/sec @ min temp Air cooled Water cooled	0.10 0.019			0.10 0.019
Readout modes	Rolling Shutter and True Global Shutter (Snapshot)			Rolling Shutter and Global Clear
Maximum dynamic range	33,000:1			33,000:1
Photon Response Non-Uniformity (PRNU) Half-light range Low light range	< 0.01% < 0.1%
User defined ROI (granularity)	Yes (1 pixel) **
Data range	12-bit (fastest USB 3.0 speeds) and 16-bit (maximum dynamic range)
Interface options	USB 3.0•8 or Camera Link
SRRF-Stream+ Compatible	No			Yes

Pixel size (W x H)	6.5 µm
Pixel well depth (e-)	30,000
Linearity (%, maximum) Full light range Low light range (< 1000 electrons signal)	Better than 99.8% Better than 99.9%
MTF (Nyquist @ 555 nm)	45%
Pixel binning	Hardware binning: 2 x 2, 3 x 3, 4 x 4, 8 x 8
Anti-blooming factor	x 10,000
I/O	External Trigger, Fire, Fire n, Fire All, Fire Any, Arm
Trigger Modes	Internal, External, External Start, External Exposure, Software Trigger
Software Exposure Events	Start exposure - End exposure (row 1), Start exposure - End exposure (row n)
Hardware timestamp accuracy	25 ns
Internal memory	1 GB

Frame Rate Table - 12-bit (16-Bit)

Array Size	ZL41 Cell 5.5 USB 3.0		ZL41 Cell 5.5 Camera Link		ZL41 Cell 4.2 Camera Link	ZL41 Cell 4.2 USB 3.0
Array Size	Rolling Shutter	Global Shutter	Rolling Shutter	Global Shutter	Rolling Shutter	Rolling Shutter
2560 x 2160	40 (30)	40 (30)	100 (75)	49 (49)
2048 x 2048	53 (40)	52 (39)	105 (98)	52 (52)	101 (101)	53 (40)
1920 x 1080	107 (80)	98 (80)	200 (200)	97 (97)	192 (192)	107 (80)
512 x 512	422 (422)	201 (201)	422 (422)	201 (201)	406 (406)	406 (406)
128 x 128	1691 (1691)	716 (716)	1691 (1691)	716 (716)	1627 (1627)	1627 (1627)
2048 x 8 (FCS mode)	13020 (10250)	4008 (4008)	27057 (27057)	4008 (4008)	26041 (26041)	13020 (10250)
1024 x 8 (FCS mode)	27057 (27057)	4008 (4008)	27057 (27057)	4008 (4008)	26041 (26041)	26041 (26041)